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. If you did download, please help us to recover it by sending a mail toÂ . Download Data after ThankÂ .The objective of the proposed research is to develop a method of specific pulmonary drug delivery that achieves a 100-fold increase in the therapeutic index of an antitumor agent in vivo and at the same time produces a 0.1-0.5 mm diameter track, which remains open for a prolonged period of time. The research will pursue this goal using a commercially available carbamoyl polystyrene copolymer (CPS), which is made up of the soluble urethane polymer. A proof-of-principle study will be carried out using a combination of pulsed ultrasound and CPS as a means of promoting drug release and thereby increasing the pulmonary tumor therapeutic index. The hypothesis is that exposure of the pulmonary transit region of the alveolar capillary to ultrasound during drug administration will promote a localized drug release from the CPS. Thus, pulsed ultrasound exposure will serve to locally disperse the drug as well as enhance its tumor selectivity. Preliminary results have established that exposure to pulsed ultrasound and a CPS saturated with antitumor drug not only enhances the therapeutic index but also significantly increases the lung retention of the drug. An animal model will be developed to demonstrate that drug localized in the pulmonary transit region is preferentially delivered to the tumor and that the therapeutic index can be increased by a factor of 1000. The results will be studied over an extended treatment period of 6 weeks and the rate of CPS degradation in the lung will be determined. Moreover, the therapeutic index can be sustained for the full treatment period if the drug is packaged in a three-layered drug delivery system consisting of an internal swellable layer of polymer that physically disperses the drug and an external layer of polymer containing the drug, which is thromboresistant. The system will be studied with ultrasound in rabbits to determine whether the rate of CPS degradation can be controlled to yield a controlled release device that is capable of prolonged in vivo application. An order of magnitude increase in the therapeutic index without an appreciable reduction in the skin toxicity of the drug will be achieved and a biocompatible polymer used as the drug carrier that remains stable for a prolonged time will be identified.The First Look at the NEW Flower Power
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Years after a terrible experience underground, a young man with a keen eye for the things we take for granted is about to go on a daring quest to break free of his chains.
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The best version of the movie in Hindi dubbed with English subtitles is 2 hour 44 minutes with the following plots. Also watch the trailer for this movie.
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