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A case is described of a female who was 64 years old and complained of heaviness in the neck, the presence of an oppressive feeling at the chest and shortness of breath; she suffered from arterial hypertension for 20 years. The immediate investigation with ECG, chest radiography and echocardiography and left ventriculography, showed that there was a dilatation of the right and left coronary vessels. After a period of eight years of clinical follow up, the patient is being treated with Acebutal with good results.T cell activation is regulated by the phosphatase SHP-1, which dephosphorylates antigen receptor proteins and thereby decreases their function.
Src homology domain-2 domain-containing protein tyrosine phosphatase (SHP-1) plays a negative regulatory role in lymphocyte activation. We found that SHP-1 is recruited to the T cell receptor (TCR) complex soon after TCR triggering and recruits other signaling proteins to the TCR complex. TCR phosphorylation on tyrosine was diminished when SHP-1 was overexpressed in Jurkat cells, but not in B cells. In the absence of SHP-1, T cells showed lower tyrosine phosphorylation in response to TCR signaling. In addition, activation of adenylyl cyclase and extracellular signal-regulated kinase were reduced after TCR ligation when SHP-1 was overexpressed in T cells. These results suggest that SHP-1-induced dephosphorylation affects the signal transduction process of TCR signaling and may play a role in the negative regulation of T cell activation.The present invention generally relates to measuring and
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