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The cardiovascular actions of the peptides endothelin and atrial natriuretic peptide (ANP) were studied in conscious normotensive rats. Intravenous infusions of both peptides (0.05-4.00 pmol/kg/min) dose-dependently increased arterial blood pressure. Atrial natriuretic peptide-induced hypotension was accompanied by a significant fall in total peripheral resistance, probably caused by increased vagal tone and/or increased cardiac output. Atrial natriuretic peptide also lowered pulmonary pressure. Neither peptide infused intravenously (0.01-0.04 pmol/kg/min) had an effect on the heart rate or intra-arterial blood pressure. The peptides increased cerebrospinal fluid concentrations of immunoreactive endothelin-1 (ir-ET-1), with a maximal effect (fourfold increase) observed after administration of the highest dose. However, in contrast to the vascular effects of the peptides, intrahypothalamic infusion of ANP (0.3-1.0 pmol/rat/min) increased heart rate and cardiac output. The above effect of ANP was associated with a significant reduction of ir-ET-1 concentrations in the cerebrospinal fluid. This study demonstrates that endothelins and ANP can act as modulators of the CNS, i.e., ir-ET-1 was detected in the cerebrospinal fluid. In contrast to the actions of the peptides on the cardiovascular system, CNS-acting mechanisms of ANP appear not to be linked to the endothelin system, but rather to another central signalling system., or I will.” I guess that’s a pretty standard golden rule in parenting, right? Parents that do this, gain the ability to be able to discipline by not facing the discipline – they just “sulk.”
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This site does not store any files on its server.Busch Stadium officials have been notified that an item posted on the team’s website asking for questions for the manager of Saturday night’s home opener has been deemed inappropriate, and will be removed.
Templates for on-field interviews were attached to the request. The request said readers were told to “answer the four questions for Jim Leyland” — acknowledging that the former Tigers manager would not be starting for the first time since retiring as a player.
Even though the items were removed, they apparently could be found on another page of the website, and pictures of them had been posted elsewhere on the Internet.
The matter was raised on the first day of spring training, when the idea of implementing a listening lounge on the field at Busch was proposed to manager Lou Piniella and then-coach Mike Borzello. The idea never came to fruition, as it was not the focus of the session.
As for Wednesday’s game, Tigers manager Jim Leyland said he does not expect any changes to the club’s starting lineup.
“I’m comfortable with what I have,” Leyland said. “If something happens, we’ll figure it out. This is not the first time we’ve done this. I’m probably a little more comfortable the closer to the opener, but I’m never too comfortable.
“It’s on the other side, and I have confidence in the guys. You guys saw it [today], the bullpen has been moving it around. We’ve been managing it a long time. We’ll figure it out.”
Win Gauntt is set to make his first career start at first base. The 19-year-old has made 24 starts this spring.
“We’re fine with our roster,” Leyland said. “I’m not ready to pull anybody in yet. We have a long way to go, and we’re still trying to get them comfortable.
“We’ve got a lot of firsts, probably a few more firsts the closer we get to the opener. Win’s going to pitch, and he’s going to have to be fine with the lineup.”
Leyland said he is fine with the infield alignment.
“If I get four good starting pitchers, I’ll be fine,” Leyland said.
Gauntt played in six games for the Tigers this spring. He